An artist named ChiaNi, who posts some of her work on Flickr, has been working on a series called Mona Lisa step by step.
It is based on her recreation of the Mona Lisa, using her own face. ChiaNi paints on a digital canvas, combining digital photos and mouse-strokes in PhotoShop.
She most often creates self-portraits in a variety of styles.
I recommend having a look at the slideshow version of her Mona Lisa series. Set the timing to 1 or 2 seconds. It's rather cool.